Effects of diabetes mellitus on semen quality in adult men: a systematic review and meta-analysis
نویسندگان
چکیده
Objective: To explore the effects of diabetes mellitus (DM) on semen parameters. Methods: The PubMed, Embase and Cochrane Library databases were searched to identify eligible studies for this meta-analysis. The most recent search was performed in December 2015. Standard mean differences (SMDs) with 95% confidence intervals (CIs) were used to evaluate the effects of DM on semen parameters. Heterogeneity among studies was examined using the Chi-square distribution based on the Q-test and I2. When I2≤50% for the Q-test, a lack of heterogeneity among the studies was indicated, and the summary estimate of each study was calculated using the fixed-effects model. Otherwise, the random-effects model was used. Results: A total of 21 independent studies (1218 cases and 1171 controls) were analysed. The results suggested that semen volume, sperm concentration, total sperm motility, progressive sperm motility and normal sperm morphology were significantly lower in DM patients than in nondiabetic controls, and the pooled SMDs (95% CIs) were -0.59 [-0.97, -0.21], -0.52 [-0.94, -0.09], -1.93 [-2.79, -1.08], -3.54 [-5.25, -1.83], and -1.08 [-1.53, -0.62], respectively, P<0.05. In addition, sperm DNA fragmentation was significantly higher in DM patients than in nondiabetic controls, and the pooled SMD (95% CI) was 1.99 [0.41, 3.56], P<0.05. However, rapid progressive sperm motility and total sperm count in DM patients were not significantly different from those in nondiabetic controls (SMDs (95% CIs) -0.85 [-1.95, 0.24], and -0.23 [-0.71, 0.25], respectively, P>0.05). Conclusion: Our study indicated that DM had negative effects on semen quality.
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